Global Initiative for Childhood Cancer: progress and challenges in Panama

ABSTRACT Despite being classified as a high-income country, Panama still faces challenges in providing care for children and adolescents with cancer. Annually, 170 new cases of childhood cancer are diagnosed in Panama, and the survival rate is around 60%. To improve this, the establishment of a Pediatric Cancer Commission comprised of healthcare professionals and nonprofit organizations has been a critical step toward the objectives outlined in the CureAll framework of the World Health Organization Global Initiative for Childhood Cancer (GICC). To improve childhood cancer care in Panama, a workshop for cancer in children and adolescents was conducted with the support of St. Jude Children’s Research Hospital, Children’s Hospital Colorado, the Ministry of Health of Panama, and the Pan American Health Organization. The commissions established were on: Nursing, Palliative Care, Psychosocial, Hospital Registry, Early Diagnosis, and Health Services. Each commission has a specific project to be implemented in the period 2021–2029 to continue the progress toward improving childhood cancer care. Since the start of implementation of the GICC in Panama, important achievements have included the launch in 2021 of the Guide for the Diagnosis of Cancer in Children and Adolescents, and training programs for primary care health personnel. Through these programs, more than 1 000 health professionals have been trained on diagnosis of cancer in childhood and adolescence. Challenges remain, such as access to quality care, and it is essential to continue efforts to improve childhood cancer care.

Cardiovascular diseases (CVD) and other noncommunicable diseases (NCDs) are the leading causes of death and disability globally, and the population affected by NCDs is increasing (1). For example, there were nearly 100 million additional healthy life-years lost in 2019, as in 2000, from heart disease, stroke, diabetes, cancer and chronic respiratory diseases (1).
In the Americas, NCDs are also the leading causes of death and account for 80.7% of all mortality in 2019, with 34% of NCD deaths occurring prematurely (between ages 30 and 70 years) (2). Although a Sustainable Development Goal target has been set for a one third reduction in premature mortality from NCDs by 2030 (SDG 3.4), this target will not be met in the Americas without significantly scaling up implementation of the cost-effective NCD risk factor policies, and clinical interventions (3). Furthermore, the SDG 3.4 target cannot be achieved by addressing a single NCD or with a single intervention, as revealed by a global analysis, demonstrating that joint interventions are necessary to reduce the risk of death from cardiovascular disease, cancer, diabetes, and chronic respiratory diseases (3).
The evidence on effectiveness and costs for policies to prevent NCDs has been well documented (4). In low-and middle-income countries, it is estimated that 32 million deaths could be averted over 10 years by enacting tobacco legislation, implementing salt reduction strategies, and providing multidrug therapy to individuals at high risk of CVD events, requiring an annual investment of US $1-$3 per capita (4). This evidence for the 'WHO NCD Best Buys' provides justification for primary prevention of NCDs. However, there is global recognition that prevention alone is insufficient, and that reducing NCD mortality will also require robust health systems with increased capacity to screen, diagnose and manage people with NCDs on a long term, continuing basis. This requires strengthening primary health care and integrating NCD management in the health system, which is the focus of this article.
NCDs often begin without any symptoms, necessitating strategies for early detection and using any health encounter as opportunities for diagnosis. Once diagnosed, people living with NCDs need continuous care over the long-term, as well as education and support to manage their condition. Furthermore, many live with multiple conditions which share similar strategies for diagnosis, treatment and control, calling for an integrated approach to better coordinate care around people's needs, rather than individual diseases.
This article provides an overview of an integrated approach to improve NCD management, as a way to address needs of people living with NCDs, along with guidance and strategies on integrating NCD management, as part of health system strengthening post COVID-19 in the Region of the Americas.

IMPROVING NCD MANAGEMENT
Coupling NCD prevention policies with health system improvements for NCDs can lead to better health and wellbeing, and lead to more rapid declines in premature NCD mortality (3). Although data are scant, there are enormous gaps in NCD care in the Americas. One estimate shows that in Latin America, 43.0% men and 28.0%, women with hypertension remain undiagnosed (5); for those with diabetes, 32.8% in Central and South America are undiagnosed (6). Although WHO STEPs surveys provide NCD prevalence data, individual data required to improve quality of care for people with NCDs is lacking.
In addition to improving data, reducing these gaps in care will depend on improving the deficiencies in the overall health system capacity for NCDs. Only 17/35 countries (49%) in the Americas report having evidence-based national guidelines/ protocols for NCD management in primary care, while only 7/35 countries (20%) report provision of drug therapy, including glycaemic control, and counselling for eligible persons at high risk to prevent heart attacks and strokes. Sixty percent of countries (21/35 countries) reported all six essential NCD tests and procedures (measurement of height, weight, blood pressure, blood glucose, and total cholesterol, as well as urine strips for albumin assay) being available in public facilities and almost all countries report availability of essential NCD medicines in primary care in the public sector (2).
To improve NCD management, globally recognized evidence-based clinical interventions have been promoted through the WHO Best Buys (7), Chronic Care Model (8), the HEARTS technical package for cardiovascular disease management in primary health care (9), the HEARTS-D module for diagnosis and management of type 2 diabetes (10), the WHO package of essential noncommunicable (PEN) disease interventions for primary health care (11) to support the timely diagnosis and treatment of the main conditions (hypertension, diabetes, cancers amenable to screening and early diagnosis, asthma and other chronic respiratory diseases), as well as the Patient-Centered Medical Home model (12). Table 1 provides a brief inventory of the main PAHO/WHO guidance documents with evidence-based recommendations which can be applied in primary care to improve NCD management. While these tools have disease-specific guidelines, they can be used in an integrated approach for NCDs, a principle to coordinate care around people's needs. Furthermore, the tools share common elements to improve quality of NCD care including use of standardized evidence-based protocols and clinical guidelines; a multi-disciplinary primary care team sufficiently trained to deliver NCD services; a core set of essential NCD medicines and technologies that are equitably available and affordable for the system and people affected; referral pathways to higher level care; information system to monitor and ensure follow up; and self-management support. Recent systematic reviews of the outcomes associated with implementing such chronic care models to manage people with diabetes, hypertension and CVD have shown improvement in outcomes, including improvements in HbA1c for diabetes, reduced risk of heart failure, better adherence to clinical guidelines, and reduced health service utilization (13,14). This was attributed to the focus on communication between health professionals and patients, availability of essential medicines, diagnostics and trained personnel, and coordination between healthcare providers (13,14). Yet, a recent systematic review indicated that implementing a chronic care model had little or no difference to achieving blood pressure control, or reducing overall mortality, although the evidence was very uncertain (15). This highlights the need for more comprehensive evaluation to better understand the contextual factors and implementation modalities that affect success of approaches to improve NCD management.

INTEGRATED APPROACH TO IMPROVE NCD MANAGEMENT
But it is not simply a matter of having guidelines, training providers and ensuring availability of essential medicines and diagnostics, to improve NCD outcomes. It requires changes in governance, service organization and financing, so that NCDs are integrated throughout the health system (Table 2), and care is coordinated around people's needs. Health systems have historically been built on a model of acute, episodic care, largely focused on infectious diseases. Over time, and with technological advances, health systems have transitioned to highly specialized, hospital-based care, away from people-centered, community-based primary care. This leads to increased segmentation and fragmentation of health services, exacerbating barriers in access to comprehensive, quality services, and poor response capacity at the first level of care, as well as increased out of pocket expenses for users (16).
For the estimated 242 million people (24% of the population) in the Americas that have at least one underlying chronic condition (17), such fragmentation has led to underdiagnosis, unnecessary procedures, or care provided at more complex levels and use of costly services (18). In fact, as an indicator of fragmentation, the hospitalization rate for chronic conditions that could be better managed at the first level of care ranged from 10.8% to 21.6% in countries in the Americas (19).
Integrated care can address fragmentation and is an approach to coordinating and delivering care across the health system, based on people's needs for continuum of care for chronic conditions, that achieves better health outcomes and improved patient experience (16). It includes establishing links between different clinical and social services at the organizational level, such as through multidisciplinary teams, and ensuring that care by providers is integrated into common processes such as shared guidelines and protocols so people receive holistic diagnosis and treatment at the point of care.
This level of integration can increase encounters with persons who would benefit from NCD diagnosis and treatment but would otherwise be missed. It aims to provide care across the continuum, from primary through secondary and specialist tertiary care, with timely referral pathways and the ability to retain patients in long-term care, rather than having vertical programs for individual diseases. Furthermore, a health information system that includes NCDs is a necessity when managing chronic conditions. This includes registering patients diagnosed with an NCD, recording any referrals, course of treatment and rates of control, notifications for timely follow up consultations, tracking progress and identifying trends in key NCD indicators. Structured and centralized information, accessible to the entire care team, can greatly aid care teams to anticipate problems, guide changes to treatment plans and reinforce patient's self-management (14).

COVID-19 AFFECTED SERVICES FOR NCD
While an integrated approach for NCD management has grown in the Region of the Americas (8), and the HEARTS in the Americas initiative has expanded throughout the Region, the COVID-19 pandemic has affected the progress. It has reinforced vertical and isolated programs, redirected scarce health resources away from NCDs, as well as had an enormous economic and social impact and disrupted care for people living with NCDs, including interruption of essential NCD medicines (20). While only one country in the Americas reported that outpatient NCD services were fully closed during the pandemic in 2020-2021, there were significant disruptions in health services, such that 54% of countries (19/35 countries) reported limited access to inpatient NCD services (20). Fear/mistrust in seeking health care (20/35 countries), decrease in outpatient volume due to patients not presenting (19/35 countries) and clinical staff deployed to COVID-19 relief (18/35 countries) were the main reasons cited for these disruptions. One of the benefits has been the expansion of telemedicine, which was used to replace in person consultations in 54% of the countries in the Region (19/35 countries) (20), although the coverage of this service has not been documented.
Health services now face the urgent task to recover from the backlog in diagnosis and treatment of persons with NCDs resulting from foregone care, while building more resilient health systems. In this transformation, there is need to evaluate the current response capacity for NCD prevention, diagnosis, and treatment.

WAY FORWARD FOR INTEGRATED NCD MANAGEMENT
Advancing integrated care for NCDs demands strategies for strengthening NCD management across all domains of the health system (see Table 2). This includes, above all, increasing primary care capacity and competencies to address multiple chronic conditions, and integration with other complementary programs to avoid missing opportunities for persons who would not otherwise be diagnosed and managed for NCDs. Opportunities for integration include services for persons with comorbidities, such as diabetes and tuberculosis; persons requiring chronic care such as patients with HIV/AIDS, particularly older adults. Sexual and reproductive health care can incorporate cervical cancer screening and gestational diabetes, while maternal and child health programs can integrate obesity.
Technology is key to expand and support integrated NCD management. This includes use of telemedicine, new technologies for laboratory tests and diagnostics, improved access to shared electronic health records, and empowering people to manage their condition with the support of mobile phone applications and self-monitoring tests. New technologies can also improve communications between patients and providers through e-consultation, patient portals, as well as interactions among providers through e-referral, integration across providers, and others. Lastly, technology can be applied to improve health information systems that better reflect NCD management by expanding the collection of clinical NCD information and using it to improve quality of care and outcomes. Core NCD indicators, such as risk factors, diagnosis, treatment coverage, treatment outcomes, should be included in national health information systems to provide critical information on NCDs.
Ultimately, integrating NCDs in primary health care is essential for moving towards universal health coverage, as well as empowering people living with NCDs. This can best be achieved by increasing the political will, funding and incentives to integrate NCDs into health systems and implement the available evidence-based tools, as governments rebuild stronger and more resilient health systems after the COVID-19 pandemic.
Author contributions. SL, IA, AH conceived the original idea. SL, IA and RC collected and analyzed the data. All authors interpreted the results. SL wrote the initial paper, all authors reviewed and contributed to the paper. All authors reviewed and approved the final version.

Conflicts of interest. None declared.
Disclaimer. The authors hold sole responsibility for the views expressed in the manuscript, which may not necessarily reflect the opinion or policy of the Revista Panamericana de Salud Pública / Pan American Journal of Public Health and/or those of the Pan American Health Organization.